KMID : 0387720210320010001
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Korean Journal of Blood Transfusion 2021 Volume.32 No. 1 p.1 ~ p.10
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Current Status of Korean Red Cross HLA-Matched Platelet Donor Registry
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Kim Yeong-Bin
Lim A-Hyun Kim Tae-Eun Jung Chul-Ho Park Min-Hui Seon Ji-Yeong Youn Kyoung-Won Lee An-Gyo Youn Mi-Ae
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Abstract
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HLA-matched platelet transfusion is required for patients with platelet refractoriness due to HLA alloimmunity.
From 2013 to 2019, the Korean Red Cross has recruited 4,080 donors for HLA-matched platelets. The patient¡¯s HLA information should be submitted to the Korean Red Cross in accordance with the WHO HLA serologic specificities. When HLA-matched platelets are requested, the Korean Red Cross selects the appropriate donors based on Duquesnoy¡¯s matching grade classification (1977) and CREGs defined by Takemoto, Fuller, and Rodey (2007) and then contacts them to request blood donations. Platelets of HLA-matched donors are collected by apheresis and supplied to the hospital. To make this process more efficient, the Korean Red Cross introduced a systemic standard work procedure using a computer program for blood donor management and HLA matching. Owing to the extensive polymorphism of the HLA types, expansion of the donor pool would be required to supply HLA-matched platelets sufficiently. As the number of registered donors for HLA-matched platelets is limited, it should only be ordered when the indication criteria for its use are met. The Korean Red Cross is planning to study genotype-based matching strategies for patients with rare HLA types and receive patients¡¯ laboratory test results from medical institutions to evaluate the effectiveness of HLA-matched platelet transfusions.
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KEYWORD
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HLA-matched platelet, Platelet refractoriness, Donor registry
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